Bio-templated bioactive glass particles with hierarchical macro-nano porous structure and drug delivery capability

Zheng K, Bortuzzo JA, Liu Y, Li W, Pischetsrieder M, Roether J, Lu M, Boccaccini AR (2014)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2014

Journal

Colloids and Surfaces B: Biointerfaces Elsevier

Book Volume: 135

Pages Range: 825-832

DOI: 10.1016/j.colsurfb.2015.03.038

Abstract

Hierarchically porous bioactive glass particles (BGPs) were synthesized by a facile sol-gel process using pollen grains as the templates. The synthesized pollen-templated bioactive glass particles (PBGPs) exhibited dual macro-nano porous structure. The macro pores (~1μm) were inherited from the template of pollen grains while the nano pores (~9.5nm) were induced by the intrinsic mechanism of the sol-gel process. PBGPs possessed a high specific surface area (111.4m/g) and pore volume (0.35cm/g). Hydroxyapatite (HA) formation on PBGPs was detected within 3 days after immersion in simulated body fluid (SBF). Due to their larger specific surface area and pore volume, PBGPs could be loaded with more tetracycline hydrochloride (TCH) than non-templated BGPs and conventional melt-derived 45S5 BGPs. In addition, PBGPs exhibited a low initial burst release (within 10% of the loaded amount) within 18h and a sustained release with a two-stage release pattern for up to 6 days in phosphate buffered saline (PBS). The antibacterial assay confirmed that the TCH-loaded PBGPs could release TCH within 5 days, and the released TCH could reach the minimum inhibitory concentration (MIC) against Escherichia coli. MTT assay indicated that PBGPs showed non-cytotoxic effects toward human hepatocellular carcinoma (Hep G2) cells after co-culture for up to 72h in vitro. These results showed that the biocompatible hierarchically macro-nano porous PBGPs are potential for bone regeneration and local drug delivery applications.

Authors with CRIS profile

Kai Zheng Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Judith Agnes Bortuzzo Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Yufang Liu Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl) Wei Li Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Monika Pischetsrieder Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl) Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Zheng, K., Bortuzzo, J.A., Liu, Y., Li, W., Pischetsrieder, M., Roether, J.,... Boccaccini, A.R. (2014). Bio-templated bioactive glass particles with hierarchical macro-nano porous structure and drug delivery capability. Colloids and Surfaces B: Biointerfaces, 135, 825-832. https://doi.org/10.1016/j.colsurfb.2015.03.038

MLA:

Zheng, Kai, et al. "Bio-templated bioactive glass particles with hierarchical macro-nano porous structure and drug delivery capability." Colloids and Surfaces B: Biointerfaces 135 (2014): 825-832.

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