Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review)

Steinmann S, Scheibe K, Erlenbach-Wuensch K, Neufert C, Schneider-Stock R (2015)

Publication Type: Journal article, Review article

Publication year: 2015

Journal

International Journal of Oncology Spandidos Publications

Book Volume: 47

Pages Range: 5-15

Journal Issue: 1

DOI: 10.3892/ijo.2015.2998

Abstract

The cytoskeleton-associated serine/threonine kinase death-associated protein kinase (DAPK) has been described as a cancer gene chameleon with functional antagonistic duality in a cell type and context specific manner. The broad range of interaction partners and substrates link DAPK to inflammatory processes especially in the gut. Herein we summarize our knowledge on the role of DAPK in different cell types that play a role under inflammatory conditions in the gut. Besides some promising experimental data suggesting DAPK as an interesting drug target in inflammatory bowel disease there are many open questions regarding direct evidence for a role of DAPK in intestinal inflammation.

Authors with CRIS profile

Sara Steinmann Professur für Experimentelle Tumorpathologie Kristina Koop Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Clemens Neufert Medizinische Fakultät Regine Schneider-Stock Professur für Experimentelle Tumorpathologie

How to cite

APA:

Steinmann, S., Scheibe, K., Erlenbach-Wuensch, K., Neufert, C., & Schneider-Stock, R. (2015). Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review). International Journal of Oncology, 47(1), 5-15. https://doi.org/10.3892/ijo.2015.2998

MLA:

Steinmann, Sara, et al. "Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review)." International Journal of Oncology 47.1 (2015): 5-15.

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