Sarker B, Singh R, Silva R, Roether J, Kaschta J, Detsch R, Schubert DW, Cicha I, Boccaccini AR (2014)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2014
Publisher: Public Library of Science
Book Volume: 9
Article Number: e107952
Journal Issue: 9
DOI: 10.1371/journal.pone.0107952
Due to the relatively poor cell-material interaction of alginate hydrogel, alginate-gelatin crosslinked (ADA-GEL) hydrogel was synthesized through covalent crosslinking of alginate di-aldehyde (ADA) with gelatin that supported cell attachment, spreading and proliferation. This study highlights the evaluation of the physico-chemical properties of synthesized ADA-GEL hydrogels of different compositions compared to alginate in the form of films. Moreover, in vitro cell-material interaction on ADA-GEL hydrogels of different compositions compared to alginate was investigated by using normal human dermal fibroblasts. Viability, attachment, spreading and proliferation of fibroblasts were significantly increased on ADA-GEL hydrogels compared to alginate. Moreover, in vitro cytocompatibility of ADA-GEL hydrogels was found to be increased with increasing gelatin content. These findings indicate that ADA-GEL hydrogel is a promising material for the biomedical applications in tissue-engineering and regeneration. Copyright:
APA:
Sarker, B., Singh, R., Silva, R., Roether, J., Kaschta, J., Detsch, R.,... Boccaccini, A.R. (2014). Evaluation of fibroblasts adhesion and proliferation on alginate-gelatin crosslinked hydrogel. PLoS ONE, 9(9). https://doi.org/10.1371/journal.pone.0107952
MLA:
Sarker, Bapi, et al. "Evaluation of fibroblasts adhesion and proliferation on alginate-gelatin crosslinked hydrogel." PLoS ONE 9.9 (2014).
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