Pfeifer L, Strobel D, Neurath M, Wildner D (2014)
Publication Type: Journal article
Publication year: 2014
Book Volume: 35
Pages Range: 364-7
Journal Issue: 4
To explore the impact of cholestasis on liver stiffness assessed by acoustic radiation force impulse (ARFI) technology.Over a period of four months, patients with sonographic cholestasis and increased cholestatic blood values (Bilirubin, ?GT, AP > 2 times ULN) scheduled for endoscopic therapy were recruited. Exclusion criteria were: known liver disease; signs of cirrhosis at ultrasound (irregular liver veins and/or surface); heart insufficiency (NYHA III-VI). ARFI (Siemens S2000), ultrasound and blood examinations were performed before and in a subgroup after successful biliary drainage.In total, 21 patients with cholestasis were included in the study. ARFI measurements were above the cut-off for cirrhosis (1.8 m/s) in all patients with a mean of 2.91 m/s ± 0.89 m/s without a history or signs of cirrhosis. Bilirubin, ?GT and AP were elevated on average to 9.7 ± 5.3 mg/dl, 1192 ± 960 U/l and 730 ± 389 U/l. A subgroup of 10 patients was measured after successful drainage. ARFI measurements declined in all patients of that subgroup on average by 0.76 m/s at a mean time interval of 4.5 days (p < 0.001).Cholestasis significantly increases liver stiffness assessed by ARFI. Therefore, it is important to exclude profound cholestasis when using ARFI for evaluating patients for liver fibrosis.
APA:
Pfeifer, L., Strobel, D., Neurath, M., & Wildner, D. (2014). Liver stiffness assessed by acoustic radiation force impulse (ARFI) technology is considerably increased in patients with cholestasis. Ultraschall in der Medizin, 35(4), 364-7. https://doi.org/10.1055/s-0034-1366057
MLA:
Pfeifer, Lukas, et al. "Liver stiffness assessed by acoustic radiation force impulse (ARFI) technology is considerably increased in patients with cholestasis." Ultraschall in der Medizin 35.4 (2014): 364-7.
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