Prevalence of monosodium urate deposits in a population of rheumatoid arthritis patients with hyperuricemia

Petsch C, Araujo EG, Englbrecht M, Bayat S, Hueber A, Lell M, Schett G, Manger B, Rech J, Cavallaro AJ (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Seminars in Arthritis and Rheumatism WB Saunders

Publisher: WB Saunders

DOI: 10.1016/j.semarthrit.2015.11.014

Abstract

To investigate the prevalence of monosodium urate (MSU) crystal deposits, indicative for gout, in a population of rheumatoid arthritis (RA) patients with concomitant hyperuricemia and to analyze the clinical and disease-specific characteristics of RA patients who exhibit MSU crystal deposits.Overall, 100 consecutive patients with the diagnosis of RA and a serum urate level above 6mg/dl underwent dual energy computed tomography (DECT) of both feet and hands to search for MSU crystals in a prospective study between October 2011 and July 2013. Presence and extent of MSU crystal deposits on DECT was assessed by automated volume measurement. Demographic and disease-specific characteristics were recorded and included into two logistic regression models to test for the factors associated with MSU crystal deposits in RA.Hyperuricemic RA patients were mostly male (55%), over 60 years of age (63 ± 11 years), had established disease (8.7 ± 10.5 years) and a mean disease activity score 28 (DAS 28) of 3.2. In total, 20 out of 100 patients displayed MSU crystal deposits in DECT. Interestingly, the majority (70%) of the RA patients positive for MSU crystal deposits were seronegative RA patients. Hence, every third seronegative RA patient had MSU crystal deposits. According to logistic regression model analysis, seronegative status correlated positively with presence of urate deposits (p = 0.019).These data show that a considerable number of RA patients display periarticular MSU crystal deposits. Seronegative patients were shown to be predominantly affected with every third patient being positive for urate deposits.

Authors with CRIS profile

Christina Petsch Lehrstuhl für Innere Medizin III Matthias Englbrecht Lehrstuhl für Innere Medizin III Axel Hueber Department of Medicine 3 – Rheumatology and Immunology Michael Lell Medizinische Fakultät Georg Schett Lehrstuhl für Innere Medizin III Bernhard Manger Professur für Rheumatologie und Klinische Immunologie Alexander Josef Cavallaro Institute of Radiology

How to cite

APA:

Petsch, C., Araujo, E.G., Englbrecht, M., Bayat, S., Hueber, A., Lell, M.,... Cavallaro, A.J. (2015). Prevalence of monosodium urate deposits in a population of rheumatoid arthritis patients with hyperuricemia. Seminars in Arthritis and Rheumatism. https://doi.org/10.1016/j.semarthrit.2015.11.014

MLA:

Petsch, Christina, et al. "Prevalence of monosodium urate deposits in a population of rheumatoid arthritis patients with hyperuricemia." Seminars in Arthritis and Rheumatism (2015).

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