Keller U, Hecht M, Harrer T, Harrer E, Schuster B, Fietkau R, Distel L (2015)
Publication Type: Journal article
Publication year: 2015
Publisher: Elsevier
Book Volume: 116
Pages Range: 323-30
Journal Issue: 2
DOI: 10.1016/j.radonc.2015.07.002
As the incidence of cancer is rising in HIV-1-infected patients, radiotherapy is used more frequently in this patient group. Strong radiation induced side effects have been reported in single patients on antiretroviral therapy. Thus we investigated whether HIV-1 itself or antiretroviral drugs could enhance radiosensitivity in patients.Radiosensitivity after in vitro irradiation of blood lymphocytes was tested in 196 individuals (80 HIV-1-infected patients and 116 healthy controls and cancer patients) using a three color fluorescence in situ hybridization approach to analyze chromosomal aberrations (B/M). Additionally, the NNRTI efavirenz and the NRTIs tenofovir and emtricitabine were tested for radiosensitizing effects in vitro.Lymphocytes from HIV-1-infected patients in the NNRTI + NRTI group were significantly more sensitive to ionizing radiation than in the other groups (patients without treatment or with NRTI + PI or HIV-negative controls). In vitro the triple medication efavirenz, tenofovir and emtricitabine leads to a reduced survival fraction and an increased activation of the DNA repair proteins H2AX, Nbs, Atm and 53BP1 in combination with ionizing radiation.HIV-1 treatment with NNRTI containing therapy regimes possibly sensitizes a subgroup of patients to ionizing radiation. Individual radiosensitivity of HIV-1-infected patients on HAART including NNRTI should be tested before starting radiotherapy.
APA:
Keller, U., Hecht, M., Harrer, T., Harrer, E., Schuster, B., Fietkau, R., & Distel, L. (2015). NNRTI-based antiretroviral therapy may increase risk of radiation induced side effects in HIV-1-infected patients. Radiotherapy and Oncology, 116(2), 323-30. https://doi.org/10.1016/j.radonc.2015.07.002
MLA:
Keller, Ulrike, et al. "NNRTI-based antiretroviral therapy may increase risk of radiation induced side effects in HIV-1-infected patients." Radiotherapy and Oncology 116.2 (2015): 323-30.
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