Subjective cognitive decline is related to CSF biomarkers of AD in patients with MCI

Wolfsgruber S, Jessen F, Koppara A, Kleineidam L, Schmidtke K, Froelich L, Kurz A, Schulz S, Hampel H, Heuser I, Peters O, Reischies FM, Jahn H, Luckhaus C, Huell M, Gertz HJ, Schroeder J, Pantel J, Rienhoff O, Ruether E, Henn F, Wiltfang J, Maier W, Kornhuber J, Wagner M (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Neurology American Academy of Neurology (AAN)

Book Volume: 84

Pages Range: 1261-8

Journal Issue: 12

DOI: 10.1212/WNL.0000000000001399

Abstract

To test whether, in individuals with mild cognitive impairment (MCI), different measures of subjective cognitive decline (SCD) in the memory domain predict abnormal CSF biomarkers of Alzheimer disease (AD).We analyzed the multicenter baseline (cross-sectional) data of 245 patients with MCI. SCD was measured quantitatively with the Subjective Memory Decline Scale (SMDS) and qualitatively by assessing particular concerns associated with self-experienced worsening of memory. Logistic regression models were used to examine associations between SCD and abnormal CSF biomarkers, taking into account objective memory impairment, depressive symptoms, and education as covariates.Abnormal CSF ?-amyloid 1-42 (A?42) and more depressive symptoms were associated with higher SMDS scores and with the report of memory concerns. Risk of abnormal CSF A?42 increased by an estimated 57% for a 1-SD increase in SMDS scores and was doubled in patients who had SMDS scores >4 or who reported memory concerns, respectively. In addition, both SCD measures predicted risk of having a biomarker signature indicative of prodromal AD defined as presence of low CSF A?42 together with either high CSF tau or CSF phosphorylated tau 181 levels.In MCI, specific aspects of SCD severity and quality are related to CSF biomarkers indicative of AD. This extends findings in pre-MCI samples and calls for an improved operational assessment of SCD in MCI. This might be useful for sample enrichment strategies for increased likelihood of AD pathology.

Authors with CRIS profile

Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie

Involved external institutions

Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE) Georg-August-Universität Göttingen DE Germany (DE) Brookhaven National Laboratory US United States (USA) (US) Goethe-Universität Frankfurt am Main DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Universität Leipzig DE Germany (DE) Albert-Ludwigs-Universität Freiburg DE Germany (DE) Heinrich-Heine-Universität Düsseldorf DE Germany (DE) Universität Hamburg (UHH) DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) University of Paris 6 - Pierre et Marie Curie / Université Paris VI Pierre et Marie Curie (UPMC) FR France (FR) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Zentralinstitut für Seelische Gesundheit DE Germany (DE) Ortenau Klinikum DE Germany (DE)

How to cite

APA:

Wolfsgruber, S., Jessen, F., Koppara, A., Kleineidam, L., Schmidtke, K., Froelich, L.,... Wagner, M. (2015). Subjective cognitive decline is related to CSF biomarkers of AD in patients with MCI. Neurology, 84(12), 1261-8. https://doi.org/10.1212/WNL.0000000000001399

MLA:

Wolfsgruber, Steffen, et al. "Subjective cognitive decline is related to CSF biomarkers of AD in patients with MCI." Neurology 84.12 (2015): 1261-8.

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