Transgenic Rat Models of Huntington's Disease

Carreira JC, Jahanshahi A, Zeef D, Kocabicak E, Vlamings R, von Hörsten S, Temel Y (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Current Topics in Behavioral Neurosciences Springer Verlag

Book Volume: 22

Pages Range: 135-47

DOI: 10.1007/7854_2013_245

Abstract

Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.

Authors with CRIS profile

Stephan von Hörsten Professur für Experimentelle Biomedizin

Involved external institutions

Maastricht University NL Netherlands (NL)

How to cite

APA:

Carreira, J.C., Jahanshahi, A., Zeef, D., Kocabicak, E., Vlamings, R., von Hörsten, S., & Temel, Y. (2015). Transgenic Rat Models of Huntington's Disease. Current Topics in Behavioral Neurosciences, 22, 135-47. https://doi.org/10.1007/7854_2013_245

MLA:

Carreira, João Casaca, et al. "Transgenic Rat Models of Huntington's Disease." Current Topics in Behavioral Neurosciences 22 (2015): 135-47.

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