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CONFORMATION OF 6-MORPHOLINO-3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES

Clark T (1993)

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Publication Status: Published

Publication Type: Journal article

Publication year: 1993

Journal

Pages Range: 1901-1905

Journal Issue: 10

DOI: 10.1039/p29930001901

Abstract

H-1 NMR spectroscopic studies established the presence of a chair conformation for endo-3-methyl-6-morpholino-3-azabicyclo[3.1.0]hexane derivatives 8a and b. This was additionally confirmed by an X-ray structural analysis of 8b. The diastereomers 10a,b and the N-demethyl-endo-morpholino compounds 9a,b, however, were found to prefer a boat conformation. The correlation between dihedral angles and ring buckle of 3-azabicyclo[3.1.0]hexane 4 was determined by MNDOC semiempirical calculations. Further structural information about this bicyclic system was obtained by HF/6-31 G* calculations for the 3-azabicyclo[3.1.0]hexane parent compounds 4 and 5.

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How to cite

APA:

Clark, T. (1993). CONFORMATION OF 6-MORPHOLINO-3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES. Journal of the Chemical Society, Perkin Transactions 2, 10, 1901-1905. https://doi.org/10.1039/p29930001901

MLA:

Clark, Timothy. "CONFORMATION OF 6-MORPHOLINO-3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES." Journal of the Chemical Society, Perkin Transactions 2 10 (1993): 1901-1905.

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