Boron containing magnetic nanoparticles for neutron capture therapy - an innovative approach for specifically targeting tumors

Tietze R, Unterweger H, Dürr S, Lyer S, Canella L, Kudejova P, Wagner FM, Petry W, Taccardi N, Alexiou C (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Applied Radiation and Isotopes Elsevier

Publisher: Elsevier

Book Volume: 106

Pages Range: 151-5

DOI: 10.1016/j.apradiso.2015.07.028

Abstract

The selective delivery of (10)B into the tumor tissue remains to be further improved for successful and reliable Boron Neutron Capture Therapy applications. Magnetic Drug Targeting using intraarterially administered superparamagnetic nanoparticles and external magnetic fields already exhibited convincing results in terms of highly efficient and selective drug deposition. Using the same technique for the targeted (10)B delivery is a promising new approach. Here, systematic irradiation experiments of phantom cubes containing different concentrations of boron and nanoparticles as well as varying three-dimensional arrangements have been performed.

Authors with CRIS profile

Rainer Tietze Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Harald Unterweger Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Stephan Dürr Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Nicola Taccardi Lehrstuhl für Chemische Reaktionstechnik (CRT) Christoph Alexiou Professur für Nanomedizin

Additional Organisation(s)

Exzellenz-Cluster Engineering of Advanced Materials (EAM)

Involved external institutions

Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Tietze, R., Unterweger, H., Dürr, S., Lyer, S., Canella, L., Kudejova, P.,... Alexiou, C. (2015). Boron containing magnetic nanoparticles for neutron capture therapy - an innovative approach for specifically targeting tumors. Applied Radiation and Isotopes, 106, 151-5. https://doi.org/10.1016/j.apradiso.2015.07.028

MLA:

Tietze, Rainer, et al. "Boron containing magnetic nanoparticles for neutron capture therapy - an innovative approach for specifically targeting tumors." Applied Radiation and Isotopes 106 (2015): 151-5.

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