Esophageal epithelial resistance
Günther C, Neumann H, Vieth M (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 32
Pages Range: 6-10
Journal Issue: 1-2
DOI: 10.1159/000357001
Abstract
Besides its important role of digestion and absorption, esophageal tissue has an essential role as a major barrier against intraluminal pathogens like hostile microorganisms and toxins. This barrier function is achieved via various mechanical, chemical, and immunological mechanisms which are typically altered in inflammatory diseases, thereby causing subsequent damage of the mucosa. In this review we will focus on the main structural and functional barriers of host defense within the esophageal mucosa, including the epithelial layer, membrane-bound and secretory mucins, and different types of defensins. In addition, we will discuss the relevance of biofilm on esophageal tissue and will illustrate the importance of different regulators of intestinal permeability like zonulin and desmosomal components.
Authors with CRIS profile
Claudia Günther
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Michael Vieth
Involved external institutions
Germany (DE)How to cite
APA:
Günther, C., Neumann, H., & Vieth, M. (2014). Esophageal epithelial resistance. Digestive Diseases, 32(1-2), 6-10. https://doi.org/10.1159/000357001
MLA:
Günther, Claudia, Helmut Neumann, and Michael Vieth. "Esophageal epithelial resistance." Digestive Diseases 32.1-2 (2014): 6-10.
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