Cytoskeletal remodeling and slow dynamics in the living cell

Bursac P, Lenormand G, Fabry B, Oliver M, Weitz DA, Viasnoff V, Butler JP, Fredberg J (2005)

Publication Type: Journal article

Publication year: 2005

Journal

Nature Materials Nature Publishing Group

Publisher: Nature Publishing Group

Book Volume: 4

Pages Range: 557-61

DOI: 10.1038/nmat1404

Abstract

Forced and spontaneous motions of microbeads tightly bound to the cytoskeleton (CSK) of human muscle cells were analyzed. HASM cells in passages 6-7 were serum-deprived for 24 h; serum deprivation arrests the cell cylce in the G1/G00 phases. It was observed that these spontaneous bead motions reflecting nanoscale CSK arrangements depended on both the approach to glass transition and energy release due to ATP hydrolysis. The results show that the trapping, intermittency, and approach to kinetic arrest are mesoscale features of CSK protein-protein interaction that link integrative phenotypic functions to the molecular events.

Authors with CRIS profile

Ben Fabry Lehrstuhl für Biophysik

Involved external institutions

Harvard University US United States (USA) (US) National University of Singapore (NUS) SG Singapore (SG)

How to cite

APA:

Bursac, P., Lenormand, G., Fabry, B., Oliver, M., Weitz, D.A., Viasnoff, V.,... Fredberg, J. (2005). Cytoskeletal remodeling and slow dynamics in the living cell. Nature Materials, 4, 557-61. https://doi.org/10.1038/nmat1404

MLA:

Bursac, Predrag, et al. "Cytoskeletal remodeling and slow dynamics in the living cell." Nature Materials 4 (2005): 557-61.

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