?CaMKII autophosphorylation mediates neuronal activation in the hippocampal dentate gyrus after alcohol and cocaine in mice
Schöpf I, Easton AC, Solati J, Golub Y, Kornhuber J, Giese KP, Müller C (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Publisher: Elsevier
Book Volume: 591
Pages Range: 65-8
DOI: 10.1016/j.neulet.2015.02.031
Abstract
Psychoactive drug-induced cellular activation is a key mechanism to promote neuronal plasticity and addiction. Alpha Ca(2+)/calmodulin-dependent protein kinase II (?CaMKII) and its autophosphorylation play a key role in the development of drug use associated behaviours. It has been suggested that ?CaMKII autophosphorylation is necessary for drug-induced neuronal activation in the mesolimbic system. Here, we show an alcohol- and cocaine-induced increase in c-fos expression in the hippocampal dentate gyrus, which is absent in ?CaMKII(T286A) autophosphorylation deficient mice. These findings may suggest a role in hippocampal ?CaMKII autophosphorylation in the acute neuroplastic effects of alcohol and cocaine.
Authors with CRIS profile
Jalal Solati
Department of Child and Adolescent Mental Health
Yulia Golub
Department of Child and Adolescent Mental Health
Johannes Kornhuber
Lehrstuhl für Psychiatrie und Psychotherapie
Christiane Müller
Medizinische Fakultät
Involved external institutions
United Kingdom (GB)How to cite
APA:
Schöpf, I., Easton, A.C., Solati, J., Golub, Y., Kornhuber, J., Giese, K.P., & Müller, C. (2015). ?CaMKII autophosphorylation mediates neuronal activation in the hippocampal dentate gyrus after alcohol and cocaine in mice. Neuroscience Letters, 591, 65-8. https://doi.org/10.1016/j.neulet.2015.02.031
MLA:
Schöpf, Isabella, et al. "?CaMKII autophosphorylation mediates neuronal activation in the hippocampal dentate gyrus after alcohol and cocaine in mice." Neuroscience Letters 591 (2015): 65-8.
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