Physical characterization of decellularized cartilage matrix for reconstructive rhinosurgery
Goldberg-Bockhorn E, Schwarz S, Elsässer A, Seitz AM, Körber L, Dürselen L, Ignatius A, Feldmann EM, Scheithauer M, Breiter R, Rotter N (2014)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2014
Journal
Book Volume: 93
Pages Range: 756-763
Journal Issue: 11
Abstract
. Material and Methods: Material geometry of decellularized cartilage was examined by microcomputed tomography as well as material characteristics by scanning and transmission electron microscopy. The expression of integrins on the surface of human chondrocytes was determined after seeding and migration into the scaffold -absp. Results: After decellularization an obvious enlargement of the matrix surface and an intensive interaction between the chondrocytes and the collagen matrix was observed. ITGA1 and ITGB1 were upregulated indicating chondrogenic differentiation -absp. Conclusion: Therefore, decellularized porcine cartilage provides an optimal microstructure for human chondrocytes with respect to cell integration and matrix production. Thus, it offers promising characteristics for clinical application in reconstructive surgery.
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Germany (DE)How to cite
APA:
Goldberg-Bockhorn, E., Schwarz, S., Elsässer, A., Seitz, A.M., Körber, L., Dürselen, L.,... Rotter, N. (2014). Physical characterization of decellularized cartilage matrix for reconstructive rhinosurgery. Laryngo-Rhino-Otologie, 93(11), 756-763. https://doi.org/10.1055/s-0034-1384531
MLA:
Goldberg-Bockhorn, Eva, et al. "Physical characterization of decellularized cartilage matrix for reconstructive rhinosurgery." Laryngo-Rhino-Otologie 93.11 (2014): 756-763.
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