Yang Y, Zheng K, Liang R, Mainka A, Taccardi N, Roether J, Detsch R, Goldmann W, Virtanen S, Boccaccini AR (2017)
Publication Type: Journal article
Publication year: 2017
Book Volume: 13
Article Number: 015001
Journal Issue: 1
Copper (Cu)-containing bioactive glass nanoparticles (Cu-BGNs) were introduced in polycaprolactone (PCL) coating systems to improve the bioactivity, antibacterial property, and corrosion resistance of vulnerable magnesium matrices under physiological conditions. The influence of different amounts of Cu-BGNs in PCL coatings was thoroughly investigated determining the wettability, electrochemical properties, and antibacterial effects against Staphylococcus carnosus and Escherichia coli, as well as their cyto-compatibility. Cu-BGNs were observed randomly scattered in PCL coatings. Increasing concentration of Cu-BGNs resulted in slightly decreasing water contact angle, and reducing anti-corrosion properties of the Cu-BGNs composite coatings. Yet higher Cu-BGNs content in coatings led to more calcium phosphate formation on the surface after 7 days of immersion in DMEM, which was confirmed by FTIR and XPS. The growth of S. carnosus and E. coli was inhibited by Cu2+ ion released from Cu-BGN coatings. In addition, both direct and indirect cyto-compatibility experiments showed that the viability and proliferation of MG-63 cells on Cu-BGN coatings were highly increased compared to pure magnesium; however, an additional increase of Cu-BGNs concentration showed a slight decrease of cell proliferation and cell activity. In summary, Cu-BGN/PCL composite coatings impart magnesium-based biomaterials antibacterial and anticorrosive properties for clinical applications.
APA:
Yang, Y., Zheng, K., Liang, R., Mainka, A., Taccardi, N., Roether, J.,... Boccaccini, A.R. (2017). Cu-releasing bioactive glass/polycaprolactone coating on Mg with antibacterial and anticorrosive properties for bone tissue engineering. Biomedical Materials, 13(1). https://doi.org/10.1088/1748-605X/aa87f2
MLA:
Yang, Yuyun, et al. "Cu-releasing bioactive glass/polycaprolactone coating on Mg with antibacterial and anticorrosive properties for bone tissue engineering." Biomedical Materials 13.1 (2017).
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