Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination

Stolt C, Wegner M (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Brain Research Elsevier

Publisher: Elsevier

Book Volume: 1641

Pages Range: 101-10

Journal Issue: Pt A

DOI: 10.1016/j.brainres.2015.09.025

Abstract

As derivatives of the neural crest, Schwann cells represent a vertebrate invention. Their development and differentiation is under control of a newly constructed, vertebrate-specific regulatory network that contains Sox10, Oct6 and Krox20 as cornerstones and central regulators of peripheral myelination. In this review, we discuss the function and relationship of these transcription factors among each other and in the context of their regulatory network, and present ideas of how neofunctionalization may have helped to recruit them to their novel task in Schwann cells. This article is part of a Special Issue entitled SI: Myelin Evolution.

Authors with CRIS profile

Claus Stolt Lehrstuhl für Biochemie und Pathobiochemie Michael Wegner Lehrstuhl für Biochemie und Pathobiochemie

Additional Organisation(s)

Emil-Fischer-Zentrum (Emil Fischer Center)

How to cite

APA:

Stolt, C., & Wegner, M. (2016). Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination. Brain Research, 1641(Pt A), 101-10. https://doi.org/10.1016/j.brainres.2015.09.025

MLA:

Stolt, Claus, and Michael Wegner. "Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination." Brain Research 1641.Pt A (2016): 101-10.

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