The age and genomic integrity of neurons after cortical stroke in humans
Huttner HB, Bergmann O, Salehpour M, Racz A, Tatarishvili J, Lindgren E, Csonka T, Csiba L, Hortobagyi T, Mehes G, Englund E, Solnestam BW, Zdunek S, Scharenberg C, Strom L, Stahl P, Sigurgeirsson B, Dahl A, Schwab S, Possnert G, Bernard S, Kokaia Z, Lindvall O, Lundeberg J, Frisen J (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Nature Publishing Group
Book Volume: 17
Pages Range: 801-3
Journal Issue: 6
DOI: 10.1038/nn.3706
Abstract
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
Authors with CRIS profile
Involved external institutions
Karolinska Institute
Sweden (SE)
Uppsala University
Sweden (SE)
University of Debrecen / Debreceni Egyetem
Hungary (HU)
Skåne University Hospital / Skånes universitetssjukhus
Sweden (SE)
Royal Institute of Technology / Kungliga Tekniska Högskolan (KTH)
Sweden (SE)
Karolinska University Hospital / Karolinska Universitetssjukhuset
Sweden (SE)
Technische Universität Dresden
Germany (DE)
Université Claude Bernard Lyon 1 (UCB)
France (FR)
Sweden (SE)
Uppsala University
Sweden (SE)
University of Debrecen / Debreceni Egyetem
Hungary (HU)
Skåne University Hospital / Skånes universitetssjukhus
Sweden (SE)
Royal Institute of Technology / Kungliga Tekniska Högskolan (KTH)
Sweden (SE)
Karolinska University Hospital / Karolinska Universitetssjukhuset
Sweden (SE)
Technische Universität Dresden
Germany (DE)
Université Claude Bernard Lyon 1 (UCB)
France (FR)
How to cite
APA:
Huttner, H.B., Bergmann, O., Salehpour, M., Racz, A., Tatarishvili, J., Lindgren, E.,... Frisen, J. (2014). The age and genomic integrity of neurons after cortical stroke in humans. Nature Neuroscience, 17(6), 801-3. https://doi.org/10.1038/nn.3706
MLA:
Huttner, Hagen B., et al. "The age and genomic integrity of neurons after cortical stroke in humans." Nature Neuroscience 17.6 (2014): 801-3.
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