Analysis of steady state recycling chromatography using equilibrium theory

Sainio T, Kaspereit M (2009)

Publication Language: English

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2009


Publisher: Elsevier

Book Volume: 66

Pages Range: 9-18

Journal Issue: 1

DOI: 10.1016/j.seppur.2008.12.005


This paper presents a method for analysis and design of steady state recycling (SSR) chromatography under arbitrary purity or yield requirements. The approach applies to SSR processes in mixed-recycle operation and allows for the direct prediction of the steady state and the design parameters without performing dynamic simulations. Therefore, it simplifies optimal design of SSR processes and evaluation of process performance, while allowing minimizing the startup time of the process. It was shown that, when the purity and/or yield of the product fractions is specified, the total injection width is the only free operating parameter in mixed-recycle SSR chromatography. Theoretical analysis of the process revealed that the productivity is necessarily lower than that of an optimized separation by batch chromatography. On the other hand, the SSR process always outperforms batch chromatography in terms of eluent consumption and product concentrations. © 2008 Elsevier B.V. All rights reserved.

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How to cite


Sainio, T., & Kaspereit, M. (2009). Analysis of steady state recycling chromatography using equilibrium theory. Separation and Purification Technology, 66(1), 9-18.


Sainio, Tuomo, and Malte Kaspereit. "Analysis of steady state recycling chromatography using equilibrium theory." Separation and Purification Technology 66.1 (2009): 9-18.

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