Analogs of the dopamine D4 receptor ligand FAUC 113 with planar- and central-chirality

Löber S, Gmeiner P, Hübner H (2002)

Publication Type: Journal article

Publication year: 2002

Journal

Tetrahedron-Asymmetry Elsevier

Publisher: Elsevier

Book Volume: 13

Pages Range: 2303-2310

DOI: 10.1016/S0957-4166(02)00639-0

Abstract

By employing yeast enzymes, natural amino acids and the Jacobsen's catalyst as sources of chirality, we have synthesized pyrazolo[1,5-a]pyridine derivatives with central- and planar-chirality as analogs of the dopamine D4 receptor ligand FAUC 113. In vitro binding experiments displayed enhanced D2 and D3 affinity for both enantiomers of the [2.2]paracyclophane 3. The C-methylpiperazine (R)-4a revealed excellent D4 selectivity. © 2002 Elsevier Science Ltd. All rights reserved.

Authors with CRIS profile

Stefan Löber Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie Harald Hübner Lehrstuhl für Pharmazeutische Chemie

How to cite

APA:

Löber, S., Gmeiner, P., & Hübner, H. (2002). Analogs of the dopamine D4 receptor ligand FAUC 113 with planar- and central-chirality. Tetrahedron-Asymmetry, 13, 2303-2310. https://doi.org/10.1016/S0957-4166(02)00639-0

MLA:

Löber, Stefan, Peter Gmeiner, and Harald Hübner. "Analogs of the dopamine D4 receptor ligand FAUC 113 with planar- and central-chirality." Tetrahedron-Asymmetry 13 (2002): 2303-2310.

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