Piperidinylpyrroles: Design, Synthesis and Binding Properties of Novel and Selective Dopamine D4 Receptor Ligands

Hübner H, Gmeiner P (1999)

Publication Type: Journal article

Publication year: 1999

Journal

Bioorganic & Medicinal Chemistry Letters Elsevier

Publisher: Elsevier

Book Volume: 9

Pages Range: 3143-3146

DOI: 10.1016/S0960-894X(99)00540-5

Abstract

Piperidinylpyrroles of type 3 were synthesized through a modified Paal-Knorr reaction. For the introduction of pyrrole-substituents high yielding transformations including Sonogashira cross-coupling reactions were utilized. Employment of the reagent TosMIC gave access to the regioisomeric oxazolyl derivatives 7 and 11 which showed the highest dopamine D4 receptor binding of the series investigated.

Authors with CRIS profile

Harald Hübner Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie

How to cite

APA:

Hübner, H., & Gmeiner, P. (1999). Piperidinylpyrroles: Design, Synthesis and Binding Properties of Novel and Selective Dopamine D4 Receptor Ligands. Bioorganic & Medicinal Chemistry Letters, 9, 3143-3146. https://doi.org/10.1016/S0960-894X(99)00540-5

MLA:

Hübner, Harald, and Peter Gmeiner. "Piperidinylpyrroles: Design, Synthesis and Binding Properties of Novel and Selective Dopamine D4 Receptor Ligands." Bioorganic & Medicinal Chemistry Letters 9 (1999): 3143-3146.

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