Gmeiner P (1995)
Publication Type: Journal article
Publication year: 1995
Publisher: Wiley-VCH Verlag
Book Volume: 328
Pages Range: 265-268
Starting from natural asparagine (1) a synthesis of the protected (S)-3,4-diaminobutanenitriles 5 and 8a-c via the β-homoserine derivative 2 is described. The amino function in position 4 was introduced by Mitsunobu-coupling or by reductive amination when a strange deformylation of the amino aldehyde 7 was observed as a side reaction. The Mitsunobu-product 5 was converted into the dibenzylamine substituted GABA 6b which was investigated for its affinity at the GABA-A receptor.
APA:
Gmeiner, P. (1995). Synthesis of (S)-3,4-Diaminobutanenitriles as Precursors for 3-Amino-GABA Derivatives. Archiv Der Pharmazie, 328, 265-268. https://doi.org/10.1002/ardp.19953280311
MLA:
Gmeiner, Peter. "Synthesis of (S)-3,4-Diaminobutanenitriles as Precursors for 3-Amino-GABA Derivatives." Archiv Der Pharmazie 328 (1995): 265-268.
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