Maschauer S, Einsiedel J, Hocke C, Hübner H, Kuwert T, Gmeiner P, Prante O (2010)
Publication Type: Journal article, Original article
Publication year: 2010
Original Authors: Maschauer S., Einsiedel J., Hocke C., Hubner H., Kuwert T., Gmeiner P., Prante O.
Publisher: American Chemical Society
Book Volume: 1
Pages Range: 224-228
Journal Issue: 5
DOI: 10.1021/ml1000728
The neurotensin receptor subtype 1 (NTS1) represents an attractive molecular target for imaging various tumors. Positron emission tomography (PET) gained widespread importance due to its sensitivity. We combined the design of a metabolically stable neurotensin analogue with a Ga-radiolabeling approach. The Ga-labeled peptoid?peptide hybrid [Ga]3 revealed high stability, specific tumor uptake (0.7%ID/g, 65 min p.i.), and advantageous biokinetics in vivo using HT29 tumor-bearing nude mice. Because of the ability to internalize into NTS1-expressing tumor cells, [Ga]3 proved to be highly suitable for a reliable and practical visualization of NTS1-expressing tumors in vivo by small animal PET. © 2010 American Chemical Society.
APA:
Maschauer, S., Einsiedel, J., Hocke, C., Hübner, H., Kuwert, T., Gmeiner, P., & Prante, O. (2010). Synthesis of a 68Ga-labeled peptoid?peptide hybrid for imaging of neurotensin receptor expression in vivo. ACS Medicinal Chemistry Letters, 1(5), 224-228. https://doi.org/10.1021/ml1000728
MLA:
Maschauer, Simone, et al. "Synthesis of a 68Ga-labeled peptoid?peptide hybrid for imaging of neurotensin receptor expression in vivo." ACS Medicinal Chemistry Letters 1.5 (2010): 224-228.
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