Synthesis, biological evaluation and radiolabelling by 18F- fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET

Höfling S, Maschauer S, Hübner H, Gmeiner P, Wester HJ, Prante O, Heinrich M (2010)

Publication Type: Journal article, Original article

Publication year: 2010

Journal

Bioorganic & Medicinal Chemistry Letters Elsevier

Original Authors: Hofling S.B., Maschauer S., Hubner H., Gmeiner P., Wester H.-J., Prante O., Heinrich M.R.

Publisher: Elsevier

Book Volume: 20

Pages Range: 6933-6937

Journal Issue: 23

DOI: 10.1016/j.bmcl.2010.09.142

Abstract

Radical F-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been successfully applied to the radiochemical synthesis of the dopamine D-selective ligand SH 317 ([ F]8). SH 317 has been evaluated as a new PET ligand candidate by in vivo experiments. © 2010 Elsevier Ltd. All rights reserved.

Authors with CRIS profile

Simone Maschauer Department of Nuclear Medicine Harald Hübner Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie Olaf Prante Professur für Molekulare Bildgebung und Radiochemie Markus Heinrich Professur für Pharmazeutische Chemie

Involved external institutions

Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Höfling, S., Maschauer, S., Hübner, H., Gmeiner, P., Wester, H.-J., Prante, O., & Heinrich, M. (2010). Synthesis, biological evaluation and radiolabelling by 18F- fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET. Bioorganic & Medicinal Chemistry Letters, 20(23), 6933-6937. https://doi.org/10.1016/j.bmcl.2010.09.142

MLA:

Höfling, Sarah, et al. "Synthesis, biological evaluation and radiolabelling by 18F- fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET." Bioorganic & Medicinal Chemistry Letters 20.23 (2010): 6933-6937.

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