The Azulene Framework as a Novel Arene Bioisostere: Design of Potent Dopamine D4 Receptor Ligands Inducing Penile Erection

Löber S, Tschammer N, Hübner H, Melis MR, Argiolas A, Gmeiner P (2009)

Publication Type: Journal article

Publication year: 2009

Journal

Publisher: Wiley-VCH Verlag

Book Volume: 4

Pages Range: 325-328

DOI: 10.1002/cmdc.200800395

Abstract

(Graph Presented) Blue makes it happen: The non-uniform charge distribution of the blue colored azulene framework is highly suitable for the bioisosteric replacement of bicyclic heteroarene moieties. Showing an analogous binding mode as heterocyclic dopamine D4 receptor-selective lead compounds, the induction of penile erection in rats over a greater range of doses indicates a putative advantage of the rationally developed azulene derivative 2 b over apomorphine. © 2009 Wiley-VCH Verlag GmbH& Co. KGaA.

Authors with CRIS profile

Additional Organisation(s)

Involved external institutions

Università degli Studi di Cagliari Italy (IT)

How to cite

APA:

Löber, S., Tschammer, N., Hübner, H., Melis, M.R., Argiolas, A., & Gmeiner, P. (2009). The Azulene Framework as a Novel Arene Bioisostere: Design of Potent Dopamine D4 Receptor Ligands Inducing Penile Erection. ChemMedChem, 4, 325-328. https://doi.org/10.1002/cmdc.200800395

MLA:

Löber, Stefan, et al. "The Azulene Framework as a Novel Arene Bioisostere: Design of Potent Dopamine D4 Receptor Ligands Inducing Penile Erection." ChemMedChem 4 (2009): 325-328.

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