Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model

Lippert E, Ruemmele P, Obermeier F, Goelder S, Kunst C, Rogler G, Dunger N, Messmann H, Hartmann A, Endlicher E (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Digestion Karger

Book Volume: 95

Pages Range: 275-280

Journal Issue: 4

DOI: 10.1159/000475524

Abstract

Colorectal cancer is the main leading cause of cancer-related deaths worldwide. Present data suggest that plant-derived anthocyanins have anti-inflammatory and chemopreventive properties. This study was aimed at evaluating the effect of an anthocyanin-rich extract from bilberries on colorectal tumour development and growth in the administration of azoxymethan (AOM)/dextran sodium sulfate (DSS) mouse model.Colonic carcinogenesis was induced by AOM and DSS 3 or 5%, respectively, in 50 female Balb/c mice. Mice received either normal food (controls) or a diet containing either 10 or 1% anthocyanin-rich bilberry extract. Colonoscopy took place at week 4 and 9 after initiation of carcinogenesis. After termination at week 9, colon samples were analysed macroscopically and microscopically.Mice receiving 10% anthocyanins showed significantly (p < 0.004) less reduced colon length (12.1 cm [8.5-14.4 cm]) as compared to controls (11.2 cm [9.8-12.3]) indicating less inflammation. Mice fed with 10% anthocyanin-rich extract revealed significantly less mean tumour numbers (n = 1.2) compared to control (n = 14) and anthocyanin 1% treated mice (n = 10.6, p < 0.001).Anthocyanins prevented the formation and growth of colorectal cancer in AOM/DSS-treated Balb/c mice. Further studies should investigate the mechanisms of how anthocyanins influence the development of colorectal cancer.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Universitätsklinikum Augsburg DE Germany (DE) Universitätsklinikum Regensburg DE Germany (DE) Universitätsspital Zürich (USZ) CH Switzerland (CH)

How to cite

APA:

Lippert, E., Ruemmele, P., Obermeier, F., Goelder, S., Kunst, C., Rogler, G.,... Endlicher, E. (2017). Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model. Digestion, 95(4), 275-280. https://doi.org/10.1159/000475524

MLA:

Lippert, Elisabeth, et al. "Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model." Digestion 95.4 (2017): 275-280.

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