Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology
Tacke D, Buchheidt D, Karthaus M, Krause S, Maschmeyer G, Neumann S, Ostermann H, Penack O, Rieger C, Ruhnke M, Sandherr M, Schweer KE, Ullmann AJ, Cornely OA (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Springer Verlag (Germany)
Book Volume: 93
Pages Range: 1449-56
Journal Issue: 9
DOI: 10.1007/s00277-014-2108-y
Abstract
Invasive fungal infections cause substantial morbidity and mortality in immunocompromised patients, particularly in those with haematological malignancies and recipients of allogeneic haematopoietic stem cell transplantation. Difficulties in diagnosing invasive fungal infections and subsequent delays in treatment initiation lead to unfavourable outcomes and emphasise the importance of prophylaxis. Since the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology in 2009, results of 14 additional clinical studies have been published comprising 2,899 patients and initiating this update. Key recommendations for adult patients are as follows: Posaconazole remains the drug of choice during remission-induction chemotherapy in acute myeloid leukaemia, myelodysplastic syndrome and allogeneic haematopoietic stem cell transplantation with graft versus host disease (AI). In the pre-engraftment period of allogeneic transplantation, several antifungals are appropriate and can be recommended with equal strength: voriconazole (BI), micafungin (BI), fluconazole (BI) and posaconazole (BII). There is poor evidence regarding antifungal prophylaxis in the post-engraftment period of allogeneic haematopoietic stem cell transplantation if no steroids for treatment of graft versus host disease are required. Aerosolised liposomal amphotericin B inhalation in conjunction with fluconazole can be used in patients with prolonged neutropenia (BII).
Authors with CRIS profile
Involved external institutions
Universitätsklinikum Köln
Germany (DE)
Universitätsklinikum Mannheim
Germany (DE)
Klinikum Neuperlach
Germany (DE)
Klinikum Ernst von Bergmann
Germany (DE)
Klinikum der Universität München (Großhadern und Innenstadt)
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Germany (DE)
Universitätsklinikum Mannheim
Germany (DE)
Klinikum Neuperlach
Germany (DE)
Klinikum Ernst von Bergmann
Germany (DE)
Klinikum der Universität München (Großhadern und Innenstadt)
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
How to cite
APA:
Tacke, D., Buchheidt, D., Karthaus, M., Krause, S., Maschmeyer, G., Neumann, S.,... Cornely, O.A. (2014). Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. Annals of Hematology, 93(9), 1449-56. https://doi.org/10.1007/s00277-014-2108-y
MLA:
Tacke, Daniela, et al. "Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology." Annals of Hematology 93.9 (2014): 1449-56.
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