Prognostic value of O-6-methylguanine-DNA methyltransferase loss in salivary gland carcinomas

Scesnaite A, Jarmalaite S, Müller M, Agaimy A, Zenk J, Hartmann A, Iro H, Peters B, Schwarz S, Schneider-Stock R (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Head and Neck-Journal For the Sciences and Specialties of the Head and Neck Wiley-Blackwell

Publisher: Wiley-Blackwell

Book Volume: 36

Pages Range: 1258-67

Journal Issue: 9

DOI: 10.1002/hed.23445

Abstract

The purpose of this study was to determine the prognostic value of O-6-methylguanine-DNA methyltransferase (MGMT) inactivation in a group of 286 patients with salivary gland carcinoma and matched histologically normal tissues.MGMT promoter methylation was studied in 36 patients with salivary gland carcinoma and 19 histologically matched normal tissues by pyrosequencing. MGMT protein expression was examined in 286 patients with salivary gland carcinomas and histologically matched normal tissues by immunohistochemistry on tissue microarrays. The results were correlated to demographic, clinicopathologic parameters, and disease follow-up data.MGMT hypermethylation was significantly (p = .021) associated with the protein loss. MGMT loss was found in 39.2% of salivary gland carcinomas and was predominant in aggressive tumors (poorly differentiated, grade III, regional lymph node involved). MGMT loss significantly (p = .004) predicted poor clinical outcome of salivary gland carcinomas and defined high-risk subgroups in clinically favorable tumor groups.We suggest that immunohistochemical evaluation of nuclear MGMT protein might serve as a tool for the prediction of overall survival in patients with salivary gland carcinoma.

Authors with CRIS profile

Maximilian Müller Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Heinrich Iro Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde Susanne Schwarz Präklinisches Experimentelles Tierzentrum (PETZ) Regine Schneider-Stock Professur für Experimentelle Tumorpathologie

Involved external institutions

Vilnius University / Vilniaus universitetas LT Lithuania (LT) Otto-von-Guericke-Universität Magdeburg DE Germany (DE)

How to cite

APA:

Scesnaite, A., Jarmalaite, S., Müller, M., Agaimy, A., Zenk, J., Hartmann, A.,... Schneider-Stock, R. (2014). Prognostic value of O-6-methylguanine-DNA methyltransferase loss in salivary gland carcinomas. Head and Neck-Journal For the Sciences and Specialties of the Head and Neck, 36(9), 1258-67. https://doi.org/10.1002/hed.23445

MLA:

Scesnaite, Asta, et al. "Prognostic value of O-6-methylguanine-DNA methyltransferase loss in salivary gland carcinomas." Head and Neck-Journal For the Sciences and Specialties of the Head and Neck 36.9 (2014): 1258-67.

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