Single-step electrochemical deposition of antimicrobial orthopaedic coatings based on a bioactive glass/chitosan/nano-silver composite system
Pishbin F, Mourino V, Gilchrist JB, Mccomb DW, Kreppel S, Salih V, Ryan MP, Boccaccini AR (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Publisher: Elsevier
Book Volume: 9
Pages Range: 7469-7479
Journal Issue: 7
DOI: 10.1016/j.actbio.2013.03.006
Abstract
Composite orthopaedic coatings with antibacterial capability containing chitosan, Bioglass® particles (9.8 μm) and silver nanoparticles (Ag-np) were fabricated using a single-step electrophoretic deposition (EPD) technique, and their structural and preliminary in vitro bactericidal and cellular properties were investigated. Stainless steel 316 was used as a standard metallic orthopaedic substrate. The coatings were compared with EPD coatings of chitosan and chitosan/Bioglass®. The ability of chitosan as both a complexing and stabilizing agent was utilized to form uniformly deposited Ag-np. Due to the presence of Bioglass® particles, the coatings were bioactive in terms of forming carbonated hydroxyapatite in simulated body fluid (SBF). Less than 7 wt.% of the incorporated silver was released over the course of 28 days in SBF and the possibility of manipulating the release rate by varying the deposition order of coating layers was shown. The low released concentration of Ag ions (<2.5 ppm) was efficiently antibacterial against Staphyloccocus aureus up to 10 days. Although chitosan and chitosan/Bioglass® coating supported proliferation of MG-63 osteoblast-like cells up to 7 days of culture, chitosan/Bioglass®/Ag-np coatings containing 342 μg of Ag-np showed cytotoxic effects. This was attributed to the relatively high concentration of Ag-np incorporated in the coatings. © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Authors with CRIS profile
Involved external institutions
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
University College London (UCL)
United Kingdom (GB)
Universidad de Buenos Aires (UBA) / University of Buenos Aires
Argentina (AR)
Ohio State University
United States (USA) (US)
United Kingdom (GB)
University College London (UCL)
United Kingdom (GB)
Universidad de Buenos Aires (UBA) / University of Buenos Aires
Argentina (AR)
Ohio State University
United States (USA) (US)
How to cite
APA:
Pishbin, F., Mourino, V., Gilchrist, J.B., Mccomb, D.W., Kreppel, S., Salih, V.,... Boccaccini, A.R. (2013). Single-step electrochemical deposition of antimicrobial orthopaedic coatings based on a bioactive glass/chitosan/nano-silver composite system. Acta Biomaterialia, 9(7), 7469-7479. https://doi.org/10.1016/j.actbio.2013.03.006
MLA:
Pishbin, F., et al. "Single-step electrochemical deposition of antimicrobial orthopaedic coatings based on a bioactive glass/chitosan/nano-silver composite system." Acta Biomaterialia 9.7 (2013): 7469-7479.
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