Fabrication and characterization of bioactive and antibacterial composites for dental applications
Chatzistavrou X, Fenno JC, Faulk D, Badylak S, Kasuga T, Boccaccini AR, Papagerakis P (2014)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2014
Journal
Publisher: Elsevier
Book Volume: 10
Pages Range: 3723-3732
Journal Issue: 8
DOI: 10.1016/j.actbio.2014.04.030
Abstract
There is an increasing clinical need to design novel dental materials that combine regenerative and antibacterial properties. In this work the characterization of a recently developed sol-gel-derived bioactive glass ceramic containing silver ions (Ag-BG) is presented. The microstructural characteristics, ion release profile, zeta potential value and changes in weight loss and pH value as a function of the immersion time of Ag-BG in Tris buffer are evaluated. Ag-BG is also incorporated into natural extracellular matrix (ECM) hydrogel to further enhance its regenerative properties. Then, the micro and macro architectures of these new composites (ECM/Ag-BG) are characterized. In addition, the antibacterial properties of these new composites are tested against Escherichia coli and Enterococcus faecalis, a bacterium commonly implicated in the pathogenesis of dental pulp infections. Cell-material interaction is also monitored in a primary culture of dental pulp cells. Our study highlights the benefits of the successful incorporation of Ag in the bioactive glass, resulting in a stable antibacterial material with long-lasting bactericidal activity. Furthermore, this work presents for the first time the fabrication of new Ag-doped composite materials, with inductive pulp-cell proliferation and antibacterial properties (ECM/Ag-BG). This advanced composite made of Ag-BG incorporated into natural ECM possesses improved properties that may facilitate potential applications in tooth regeneration approaches. © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Authors with CRIS profile
Involved external institutions
University of Michigan
United States (USA) (US)
Nagoya Institute of Technology / 名古屋工業大学 Nagoya Kōgyō Daigaku
Japan (JP)
University of Pittsburgh
United States (USA) (US)
Carnegie Mellon University
United States (USA) (US)
United States (USA) (US)
Nagoya Institute of Technology / 名古屋工業大学 Nagoya Kōgyō Daigaku
Japan (JP)
University of Pittsburgh
United States (USA) (US)
Carnegie Mellon University
United States (USA) (US)
How to cite
APA:
Chatzistavrou, X., Fenno, J.C., Faulk, D., Badylak, S., Kasuga, T., Boccaccini, A.R., & Papagerakis, P. (2014). Fabrication and characterization of bioactive and antibacterial composites for dental applications. Acta Biomaterialia, 10(8), 3723-3732. https://doi.org/10.1016/j.actbio.2014.04.030
MLA:
Chatzistavrou, Xanthippi, et al. "Fabrication and characterization of bioactive and antibacterial composites for dental applications." Acta Biomaterialia 10.8 (2014): 3723-3732.
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