Toughening and functionalization of bioactive ceramic and glass bone scaffolds by biopolymer coatings and infiltration: a review of the last 5 years

Philippart A, Boccaccini AR, Fleck C, Schubert DW, Roether J (2015)

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2015

Journal

Expert Review of Medical Devices Expert Reviews (formerly Future Drugs)

Publisher: Expert Reviews (formerly Future Drugs)

Book Volume: 12

Pages Range: 93-111

Journal Issue: 1

DOI: 10.1586/17434440.2015.958075

Abstract

Inorganic scaffolds with high interconnected porosity based on bioactive glasses and ceramics are prime candidates for applications in bone tissue engineering. These materials however exhibit relatively low fracture strength and high brittleness. A simple and effective approach to improve the toughness is to combine the basic scaffold structure with polymer coatings or through the formation of interpenetrating polymer-bioactive ceramic microstructures. The polymeric phase can additionally serve as a carrier for growth factors and therapeutic drugs, thus adding biological functionalities. The present paper reviews the state-of-the art in the field of polymer coated and infiltrated bioactive inorganic scaffolds. Based on the notable combination of bioactivity, improved mechanical properties and drug or growth factor delivery capability, this scaffold type is a candidate for bone and osteochondral regeneration strategies. Remaining challenges for the improvement of the materials are discussed and opportunities to broaden the application potential of this scaffold type are also highlighted.

Authors with CRIS profile

Anahi Philippart Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Dirk Schubert Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) (LSP) Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) (LSP)

Involved external institutions

Technische Universität Berlin DE Germany (DE)

How to cite

APA:

Philippart, A., Boccaccini, A.R., Fleck, C., Schubert, D.W., & Roether, J. (2015). Toughening and functionalization of bioactive ceramic and glass bone scaffolds by biopolymer coatings and infiltration: a review of the last 5 years. Expert Review of Medical Devices, 12(1), 93-111. https://doi.org/10.1586/17434440.2015.958075

MLA:

Philippart, Anahi, et al. "Toughening and functionalization of bioactive ceramic and glass bone scaffolds by biopolymer coatings and infiltration: a review of the last 5 years." Expert Review of Medical Devices 12.1 (2015): 93-111.

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