A model of the mechanical degradation of foam replicated scaffolds

Sulong MA, Belova IV, Boccaccini AR, Murch GE, Fiedler T (2016)

Publication Status: Published

Publication Type: Journal article

Publication year: 2016


Publisher: Springer Verlag (Germany)

Book Volume: 51

Pages Range: 3824-3835

Journal Issue: 8

DOI: 10.1007/s10853-015-9701-x


Tissue engineering scaffolds are implants that actively support tissue growth whilst providing mechanical support. For optimum functionality, they are designed to slowly dissolve in vivo so that no foreign material remains permanently implanted inside the body. The current study uses a simple degradation model that estimates the change of scaffold geometry due to surface erosion. This model is applied on scaffolds that have been manufactured using the foam replication method. In order to capture their complex geometry, micro-computed tomography scans of samples are obtained. Their change in geometry and degradation of mechanical properties is evaluated using computational analysis. The present investigation found that the mechanical properties such as the quasi-elastic gradient, 0.2 % offset yield stress and the plateau stress are decreased systematically over a 10-week period of immersion time. Deformation analysis on the titania foam scaffold is performed by means of the deformed model obtained from finite element calculations.

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Sulong, M.A., Belova, I.V., Boccaccini, A.R., Murch, G.E., & Fiedler, T. (2016). A model of the mechanical degradation of foam replicated scaffolds. Journal of Materials Science, 51(8), 3824-3835. https://dx.doi.org/10.1007/s10853-015-9701-x


Sulong, M. A., et al. "A model of the mechanical degradation of foam replicated scaffolds." Journal of Materials Science 51.8 (2016): 3824-3835.

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