Time-dependent aroma changes in breast milk after oral intake of a pharmacological preparation containing 1,8-cineole
Kirsch F, Beauchamp J, Büttner A (2012)
Publication Status: Published
Publication Type: Journal article
Publication year: 2012
Journal
Publisher: Elsevier
Book Volume: 31
Pages Range: 682-692
Journal Issue: 5
DOI: 10.1016/j.clnu.2012.02.002
Abstract
Background & aims
This study investigates time-dependent aroma changes in human milk after intake of an odorant-containing pharmaceutical preparation by correlating sensory evaluation with quantitative results.
Methods
Human milk donors ingested 100 mg of encapsulated 1,8-cineole. 21 milk samples from 12 participants underwent sensory analysis, of which 14 samples were quantified by stable isotope dilution assay (SIDA) analysis. Furthermore, several consecutive breast milk and exhaled breath gas samples from one volunteer after intake of 1,8-cineole were analysed by proton-transfer-reaction mass spectrometry (PTR-MS) and sensory evaluation on three separate days.
Results
The emergence of the characteristic eucalyptus-like odour of 1,8-cineole in exhaled breath after capsule ingestion coincided with its transfer into milk; its presence in breath was therefore used to indicate the time at which milk should be expressed for gathering samples. Odorant transfer could not be confirmed by sensory analysis in 7 of the 21 milk samples, most likely due to disadvantageous timing of milk expression. The other 14 samples exhibited a distinct eucalyptus-like odour. Quantitative results matched these observations with <20 μg/kg 1,8-cineole in the odourless samples and 70 to an estimated 2090 μg/kg 1,8-cineole in the other samples.
Conclusions:
Transfer of 1,8-cineole into human milk after oral intake is time dependent and exhibits large inter and intra-individual differences. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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Germany (DE)How to cite
APA:
Kirsch, F., Beauchamp, J., & Büttner, A. (2012). Time-dependent aroma changes in breast milk after oral intake of a pharmacological preparation containing 1,8-cineole. Clinical Nutrition, 31(5), 682-692. https://doi.org/10.1016/j.clnu.2012.02.002
MLA:
Kirsch, Frauke, Jonathan Beauchamp, and Andrea Büttner. "Time-dependent aroma changes in breast milk after oral intake of a pharmacological preparation containing 1,8-cineole." Clinical Nutrition 31.5 (2012): 682-692.
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