Azaindole Derivatives with High Affinity for the Dopamine D4 Receptor: Synthesis, Ligand Binding Studies and Comparison of Molecular Electrostatic Potential Maps

Löber S, Hübner H, Gmeiner P (1999)

Publication Type: Journal article

Publication year: 1999

Journal

Bioorganic & Medicinal Chemistry Letters Elsevier

Publisher: Elsevier

Book Volume: 9

Pages Range: 97-102

DOI: 10.1016/S0960-894X(98)00692-1

Abstract

Piperazinylmethyl substituted pyrazolo[1,5-a]pyridines and related heterocycles were synthesized and found to recognize selectively the dopamine D4 receptor. For the most potent derivative 10d a Ki value of 2.0 nM was observed. SAR studies including the comparison of molecular isopotential surfaces were performed.

Authors with CRIS profile

Stefan Löber Lehrstuhl für Pharmazeutische Chemie Harald Hübner Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie

How to cite

APA:

Löber, S., Hübner, H., & Gmeiner, P. (1999). Azaindole Derivatives with High Affinity for the Dopamine D4 Receptor: Synthesis, Ligand Binding Studies and Comparison of Molecular Electrostatic Potential Maps. Bioorganic & Medicinal Chemistry Letters, 9, 97-102. https://doi.org/10.1016/S0960-894X(98)00692-1

MLA:

Löber, Stefan, Harald Hübner, and Peter Gmeiner. "Azaindole Derivatives with High Affinity for the Dopamine D4 Receptor: Synthesis, Ligand Binding Studies and Comparison of Molecular Electrostatic Potential Maps." Bioorganic & Medicinal Chemistry Letters 9 (1999): 97-102.

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