Conformationally restricted peptide mimetics by ring-closing olefin metathesis

Wakchaure S, Einsiedel J, Waibel R, Gmeiner P (2012)

Publication Language: English

Publication Type: Journal article, Original article

Publication year: 2012

Journal

Synthesis-Stuttgart Thieme Publishing / Georg Thieme Verlag

Original Authors: Wakchaure S., Einsiedel J., Waibel R., Gmeiner P.

Publisher: Thieme Publishing / Georg Thieme Verlag

Book Volume: 44

Pages Range: 2682-2694

Journal Issue: 17

DOI: 10.1055/s-0032-1316758

Abstract

Elegant chemical methodology restricting the backbone flexibility of biologically active peptides has attracted growing interest. A practical synthetic strategy is presented to access ten-membered lactam peptide mimetics. Employing a ring-closing olefin metathesis as the key reaction step, the cyclic olefin moiety was obtained with cis configuration. Conformational investigations were performed with two model peptides. © Georg Thieme Verlag Stuttgart New York.

Authors with CRIS profile

Satish Wakchaure Lehrstuhl für Pharmazeutische Chemie Jürgen Einsiedel Lehrstuhl für Pharmazeutische Chemie Reiner Waibel Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie

Additional Organisation(s)

Emil-Fischer-Zentrum (Emil Fischer Center)

How to cite

APA:

Wakchaure, S., Einsiedel, J., Waibel, R., & Gmeiner, P. (2012). Conformationally restricted peptide mimetics by ring-closing olefin metathesis. Synthesis-Stuttgart, 44(17), 2682-2694. https://doi.org/10.1055/s-0032-1316758

MLA:

Wakchaure, Satish, et al. "Conformationally restricted peptide mimetics by ring-closing olefin metathesis." Synthesis-Stuttgart 44.17 (2012): 2682-2694.

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