Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications

Basnett P, Ching KY, Stolz M, Knowles JC, Boccaccini AR, Smith C, Locke IC, Keshavarz T, Roy I (2013)

Publication Type: Journal article

Publication year: 2013


Publisher: Elsevier

Book Volume: 73

Pages Range: 1340-1348

Journal Issue: 10

DOI: 10.1016/j.reactfunctpolym.2013.03.019


Novel Poly(3-hydroxybutyrate)/Poly(3-hydroxyoctanoate) blends were developed with varying amounts of Poly(3-hydroxyoctanoate), P(3HO) and Poly(3-hydroxybutyrate), P(3HB) for their potential use in various medical applications. These blend films exhibited higher tensile strength and Young's modulus values compared to neat P(3HO). The overall protein adsorption and % cell viability was also found to be significantly higher in the blend films than the neat P(3HO) film. Hydrolytic degradation was faster in the blend films and the degradation rate could potentially be tailored to achieve the optimum rate required for a particular medical application. Hence, these novel blends were found to be highly biocompatible with surface, mechanical and thermal properties suitable for a range of potential medical applications, a great step forward in the area of medical materials. © 2013 Elsevier Ltd. All rights reserved.

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Basnett, P., Ching, K.Y., Stolz, M., Knowles, J.C., Boccaccini, A.R., Smith, C.,... Roy, I. (2013). Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications. Reactive & Functional Polymers, 73(10), 1340-1348.


Basnett, P., et al. "Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications." Reactive & Functional Polymers 73.10 (2013): 1340-1348.

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