Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes

Nadler Z, Wang B, Wollstein G, Nevins J, Ishikawa H, Kagemann L, Sigal I, Ferguson D, Hammer D, Grulkowski I, Liu JJ, Kraus M, Lu CD, Hornegger J, Fujimoto JG, Schuman J (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Biomedical Optics Express Optical Society of America

Publisher: Optical Society of America

Book Volume: 4

Pages Range: 2596–2608

Journal Issue: 11

DOI: 10.1364/BOE.4.002596

Abstract

We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of the automated technique. The method was validated using two prototype OCT devices; each had a subject cohort including both healthy and glaucomatous eyes. Automated segmentation of in-vivo 3D LC OCT microstructure performed comparably to manual segmentation and is useful for investigative research and in clinical quantification of the LC. © 2013 Optical Society of America.

Authors with CRIS profile

Martin Kraus Lehrstuhl für Informatik 14 (Bild- und Sprachverarbeitung) Joachim Hornegger Lehrstuhl für Informatik 14 (Bild- und Sprachverarbeitung)

Involved external institutions

University of Pittsburgh US United States (USA) (US) Massachusetts Institute of Technology (MIT) US United States (USA) (US) Physical Science Inc. US United States (USA) (US) Center for Devices and Radiological Health, Food and Drug Administration US United States (USA) (US)

How to cite

APA:

Nadler, Z., Wang, B., Wollstein, G., Nevins, J., Ishikawa, H., Kagemann, L.,... Schuman, J. (2013). Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes. Biomedical Optics Express, 4(11), 2596–2608. https://doi.org/10.1364/BOE.4.002596

MLA:

Nadler, Zach, et al. "Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes." Biomedical Optics Express 4.11 (2013): 2596–2608.

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