Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass (R) composites

Misra SK, Mohn D, Brunner TJ, Stark WJ, Philip SE, Roy I, Salih V, Knowles JC, Boccaccini AR (2008)

Publication Type: Journal article

Publication year: 2008

Journal

Biomaterials Elsevier

Publisher: Elsevier

Pages Range: 1750-1761

Journal Issue: 29

DOI: 10.1016/j.biomaterials.2007.12.040

Abstract

This study compares the effects of introducing micro (m-BG) and nanoscale (n-BG) bioactive glass particles on the various properties (thermal, mechanical and microstructural) of poly(3hydroxybutyrate) (P(3HB))/bioactive glass composite systems. P(3HB)/bioactive glass composite films with three different concentrations of m-BG and n-BG (10, 20 and 30 wt%, respectively) were prepared by a solvent casting technique. The addition of n-BG particles had a significant stiffening effect on the composites, modulus when compared with m-BG. However, there were no significant differences in the thermal properties of the composites due to the addition of n-BG and m-BG particles. The systematic addition of n-BG particles induced a nanostructured topography on the surface of the composites, which was not visible by SEM in m-BG composites. This surface effect induced by n-BG particles considerably improved the total protein adsorption on the n-BG composites compared to the unfilled polymer and the m-BG composites. A short term in vitro degradation (30 days) study in simulated body fluid (SBF) showed a high level of bioactivity as well as higher water absorption for the P(3HB)/n-BG composites. Furthermore, a cell proliferation study using MG-63 cells demonstrated the good biocompatibility of both types of P(3HB)/bioactive glass composite systems. The results of this investigation confirm that the addition of nanosized bioactive glass particles had a more significant effect on the mechanical and structural properties of a composite system in comparison with microparticles, as well as enhancing protein adsorption, two desirable effects for the application of the composites in tissue engineering. © 2008 Elsevier Ltd. All rights reserved.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich CH Switzerland (CH) University of Westminster GB United Kingdom (GB) University College London (UCL) GB United Kingdom (GB)

How to cite

APA:

Misra, S.K., Mohn, D., Brunner, T.J., Stark, W.J., Philip, S.E., Roy, I.,... Boccaccini, A.R. (2008). Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass (R) composites. Biomaterials, 29, 1750-1761. https://doi.org/10.1016/j.biomaterials.2007.12.040

MLA:

Misra, Superb K., et al. "Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass (R) composites." Biomaterials 29 (2008): 1750-1761.

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