Deciphering the pro-fibrotic phenotype of fibroblasts in systemic sclerosis

Maier C, Distler J, Beyer C (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Experimental Dermatology Wiley

Book Volume: 23

Pages Range: 99-100

Journal Issue: 2

DOI: 10.1111/exd.12237

Abstract

LeRoy's seminal work on the phenotypic features of scleroderma fibroblasts has been directing fibrosis research in the field of systemic sclerosis (SSc, scleroderma) for the past 30 years. His principal experiment, to culture skin fibroblasts from patients with SSc and study their pro-fibrotic phenotype in comparison with skin fibroblasts from healthy individuals, has been used by most basic and translational fibrosis studies in SSc. LeRoy's findings have revolutionized our understanding of the disease pathogenesis and guided the development of novel antifibrotic therapies towards fibroblast-specific approaches.

Authors with CRIS profile

Jörg Distler Professur für Molekulare Mechanismen der Organfibrose Christian Beyer Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Maier, C., Distler, J., & Beyer, C. (2014). Deciphering the pro-fibrotic phenotype of fibroblasts in systemic sclerosis. Experimental Dermatology, 23(2), 99-100. https://doi.org/10.1111/exd.12237

MLA:

Maier, Christiane, Jörg Distler, and Christian Beyer. "Deciphering the pro-fibrotic phenotype of fibroblasts in systemic sclerosis." Experimental Dermatology 23.2 (2014): 99-100.

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