IL-33 induces skin inflammation with mast cell and neutrophil activation
Hueber A, Alves-Filho JC, Asquith DL, Michels C, Millar NL, Reilly JH, Graham GJ, Liew FY, Miller AM, Mcinnes IB (2011)
Publication Type: Journal article
Publication year: 2011
Journal
Book Volume: 41
Pages Range: 2229-37
Journal Issue: 8
Abstract
Psoriasis is a common chronic autoimmune condition of the skin characterized by hyperplasia of epidermal keratinocytes associated with pro-inflammatory cytokines. IL-33 is a new member of the IL-1 superfamily that signals through the ST2 receptor and was originally defined as an inducer of T helper 2 (Th2) cytokines. Recently, broader immune activatory potential has been defined for IL-33 particularly via mast cell activation and neutrophil migration. Here, we show that ST2(-/-) mice exhibit reduced cutaneous inflammatory responses compared with WT mice in a phorbol ester-induced model of skin inflammation. Furthermore, injections of IL-33 into the ears of mice induce an inflammatory skin lesion. This inflammatory response was partially dependent on mast cells as mast cell-deficient mice (Kit(W-sh/W-sh) ) showed delayed responses to IL-33. IL-33 also recruited neutrophils to the ear, an effect mediated in part by increased production of the chemokine KC (CXCL1). Finally, we show that IL-33 expression is up-regulated in the epidermis of clinical psoriatic lesions, compared with healthy skin. These results therefore demonstrate that IL-33 may play a role in psoriasis-like plaque inflammation. IL-33 targeting may provide a new treatment strategy for psoriasis.
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APA:
Hueber, A., Alves-Filho, J.C., Asquith, D.L., Michels, C., Millar, N.L., Reilly, J.H.,... Mcinnes, I.B. (2011). IL-33 induces skin inflammation with mast cell and neutrophil activation. European Journal of Immunology, 41(8), 2229-37. https://doi.org/10.1002/eji.201041360
MLA:
Hueber, Axel, et al. "IL-33 induces skin inflammation with mast cell and neutrophil activation." European Journal of Immunology 41.8 (2011): 2229-37.
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