Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma

Graser A, Ekici AB, Sopel N, Melichar VO, Zimmermann T, Papadopoulos NG, Taka S, Ferrazzi F, Vuorinen T, Finotto S (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Mucosal Immunology Nature Publishing Group: Open Access Hybrid Model Option A

Book Volume: 9

Pages Range: 1183-92

Journal Issue: 5

DOI: 10.1038/mi.2015.130

Abstract

The proinflammatory cytokine interleukin-17A (IL-17A) is known to mediate antimicrobial activity, but its role during rhinovirus (RV) infections and in asthma needs further investigation. Therefore, we addressed the role of IL-17A during allergic asthma and antiviral immune response in human and murine immunocompetent cells. In this study we found that asthmatic children with a RV infection in their upper airways have upregulated mRNA levels of the antiviral cytokine interferon type I (IFN)-? and the transcription factor T-box 21 (TBX21) and reduced levels of IL-17A protein in their peripheral blood mononuclear cells (PBMCs). We also found that IL-17A inhibited RV1b replication in infected human lung epithelial cells A549. Furthermore, by using gene array analysis we discovered that targeted deletion of Il17a in murine lung CD4(+) T cells impaired Oas1g mRNA downstream of Ifn?, independently from RV infection. Additionally, in PBMCs of children with a RV infection in their nasalpharyngeal fluid OAS1 gene expression was found downregulated. Finally RV1b inhibited IL-17A production in lung CD4(+) T cells in a setting of experimental asthma. These results indicate that the RV1b inhibits IL-17A in T helper type 17 cells and IL-17A clears RV1b infection in epithelial cells. In both cases IL-17A contributes to fend off RV1b infection by inducing genes downstream of interferon type I pathway.

Authors with CRIS profile

Anna Graser Department of Molecular Pneumology Arif Bülent Ekici Institute of Human Genetics Nina Sopel Department of Molecular Pneumology Theodor Zimmermann Medizinische Fakultät Fulvia Ferrazzi Institute of Human Genetics Susetta Neurath-Finotto Department of Molecular Pneumology

Involved external institutions

National and Kapodistrian University of Athens GR Greece (GR) University of Turku / Turun yliopisto FI Finland (FI)

How to cite

APA:

Graser, A., Ekici, A.B., Sopel, N., Melichar, V.O., Zimmermann, T., Papadopoulos, N.G.,... Finotto, S. (2016). Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma. Mucosal Immunology, 9(5), 1183-92. https://doi.org/10.1038/mi.2015.130

MLA:

Graser, Anna, et al. "Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma." Mucosal Immunology 9.5 (2016): 1183-92.

BibTeX: Download