Gelatin coated 45S5 Bioglass®-derived scaffolds for bone tissue engineering

Metze AL, Grimm A, Nooeaid P, Roether J, Hum J, Newby P, Schubert DW, Boccaccini AR (2013)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2013


Publisher: Trans Tech Publications

Book Volume: 541

Pages Range: 31-39

DOI: 10.4028/


Highly porous 45S5 Bioglass® scaffolds were fabricated by the foam replica method and successfully coated with a well attached gelatin layer by dipping and pipetting methods. Depending on macropore size of the scaffold and gelatin concentration, mechanically enhanced scaffolds with improved compressive strength in comparison to uncoated scaffolds could be obtained while preserving the high and interconnected porosity that is required for bone in-growth. Moreover, the scaffolds bioactivity by immersion in simulated body fluid (SBF) was investigated showing that gelatin coating preserves the intrinsic bioactivity of the Bioglass® scaffold. It was also shown that the gelatin layer can be loaded with tetracycline hydrochloride for developing scaffolds with drug delivery capability.

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Metze, A.-L., Grimm, A., Nooeaid, P., Roether, J., Hum, J., Newby, P.,... Boccaccini, A.R. (2013). Gelatin coated 45S5 Bioglass®-derived scaffolds for bone tissue engineering. Key Engineering Materials, 541, 31-39.


Metze, Anke-Lisa, et al. "Gelatin coated 45S5 Bioglass®-derived scaffolds for bone tissue engineering." Key Engineering Materials 541 (2013): 31-39.

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