Replication of the association between CHRNA4 rs1044396 and harm avoidance in a large population-based sample

Bey K, Lennertz L, Markett S, Petrovsky N, Gallinat J, Gruender G, Spreckelmeyer KN, Wienker TF, Mobascher A, Dahmen N, Thürauf N, Kornhuber J, Kiefer F, Toliat MR, Nuernberg P, Winterer G, Wagner M (2016)

Publication Type: Journal article

Publication year: 2016

Journal

European Neuropsychopharmacology Elsevier

Book Volume: 26

Pages Range: 150-5

Journal Issue: 1

DOI: 10.1016/j.euroneuro.2015.11.007

Abstract

Harm avoidance is a personality trait characterized by excessive worrying and fear of uncertainty, which has repeatedly been related to anxiety disorders. Converging lines of research in rodents and humans point towards an involvement of the nicotinic cholinergic system in the modulation of anxiety. Most notably, the rs1044396 polymorphism in the CHRNA4 gene, which codes for the ?4 subunit of the nicotinic acetylcholine receptor, has been linked to negative emotionality traits including harm avoidance in a recent study. Against this background, we investigated the association between harm avoidance and the rs1044396 polymorphism using data from N=1673 healthy subjects, which were collected in the context of the German multi-centre study ?Genetics of Nicotine Dependence and Neurobiological Phenotypes?. Homozygous carriers of the C-allele showed significantly higher levels of harm avoidance than homozygous T-allele carriers, with heterozygous subjects exhibiting intermediate scores. The effect was neither modulated by age or gender nor by smoking status. By replicating previous findings in a large population-based sample for the first time, the present study adds to the growing evidence suggesting an involvement of nicotinic cholinergic mechanism in anxiety and negative emotionality, which may pose an effective target for medical treatment.

Authors with CRIS profile

Norbert Thürauf Medizinische Fakultät Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie

Involved external institutions

Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Universität zu Köln DE Germany (DE) Zentralinstitut für Seelische Gesundheit DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Max-Planck-Institut für molekulare Genetik / Max Planck Institute for Molecular Genetics DE Germany (DE) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE)

How to cite

APA:

Bey, K., Lennertz, L., Markett, S., Petrovsky, N., Gallinat, J., Gruender, G.,... Wagner, M. (2016). Replication of the association between CHRNA4 rs1044396 and harm avoidance in a large population-based sample. European Neuropsychopharmacology, 26(1), 150-5. https://doi.org/10.1016/j.euroneuro.2015.11.007

MLA:

Bey, Katharina, et al. "Replication of the association between CHRNA4 rs1044396 and harm avoidance in a large population-based sample." European Neuropsychopharmacology 26.1 (2016): 150-5.

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