Modeling of Drug Release From Collagen Matrices

Radu AF, Bause M, Knabner P, Lee G, Friess W (2002)

Publication Type: Journal article

Publication year: 2002

Journal

Journal of Pharmaceutical Sciences Wiley-Blackwell

Publisher: Wiley-Blackwell

Book Volume: 91

Pages Range: 964-972

Journal Issue: 4

URI: https://www1.am.uni-erlangen.de/research/publications/Jahr_2002/2002_RaduBauseKnLeeFriess_ModelingOfDrugReleaseFromCollagenMatrices

DOI: 10.1002/jps.10098

Abstract

Drug release from collagen matrices is in most cases governed by diffusion from swollen matrices but also enzymatic matrix degradation or hydrophobic drug/ collagen interactions may contribute. To reduce water uptake and to prolong the release, insoluble collagen matrices have been chemically or dehydrothermally cross-linked. Assuming Fickian diffusion a one-dimensional model was developed and tested that allows description of water penetration, swelling and drug release and that may be expanded considering a subsequent erosion process or interactions. Swelling is described by a volume balance. For dry collagen matrices crosslinked by thermal treatment the existence of a moving front separating the polymer from a gel phase was considered, and a convective term induced by the volume expansion was incorporated. The resulting moving boundary problem was solved using a method based on biquadratic finite elements in both space and time that is stable, shows high accuracy, and is suitable for solving problems with a singularity at the initial time point. The model was verified for insoluble collagen matrices at different crosslinking degrees for both chemical and thermal treatment. For constant diffusion coefficients a close form of the solution was derived yielding equivalent results to the numerical approach. © 2002 Wiley-Liss, Inc.

Authors with CRIS profile

Peter Knabner Lehrstuhl für Angewandte Mathematik (Modellierung und Numerik) Geoffrey Lee Lehrstuhl für Pharmazeutische Technologie und Biopharmazie

Involved external institutions

University of Bergen / Universitetet i Bergen NO Norway (NO)

How to cite

APA:

Radu, A.F., Bause, M., Knabner, P., Lee, G., & Friess, W. (2002). Modeling of Drug Release From Collagen Matrices. Journal of Pharmaceutical Sciences, 91(4), 964-972. https://doi.org/10.1002/jps.10098

MLA:

Radu, Adrian Florin, et al. "Modeling of Drug Release From Collagen Matrices." Journal of Pharmaceutical Sciences 91.4 (2002): 964-972.

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