Surprising prenatal toxicity of epidermal lipoxygenase-3

Vierling F, Dick A, Wahlbuhl M, Krieg P, Henke C, Ruebner M, Schneider H (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Placenta Elsevier

Publisher: Elsevier

Book Volume: 35

Pages Range: 776-9

Journal Issue: 9

DOI: 10.1016/j.placenta.2014.07.004

Abstract

Metabolites of the epidermal lipoxygenase-3 (eLOX-3) are involved in various metabolic pathways. Most unexpectedly, intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, resulted in fetal growth restriction and intrauterine death. Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicated a lack of glycogen trophoblasts in the junctional zone. Placenta-specific gene expression was altered. Thus, the observed prenatal toxicity of eLOX-3 could be due to a strong effect on placental development.

Authors with CRIS profile

Angela Dick Lehrstuhl für Genetik Mandy Wahlbuhl-Becker Department of Paediatrics and Adolescent Medicine Christine Henke Department of Obstetrics and Gynaecology Holm Schneider Professur für Kinderheilkunde/Experimentelle Perinatalmedizin

Involved external institutions

Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE)

How to cite

APA:

Vierling, F., Dick, A., Wahlbuhl, M., Krieg, P., Henke, C., Ruebner, M., & Schneider, H. (2014). Surprising prenatal toxicity of epidermal lipoxygenase-3. Placenta, 35(9), 776-9. https://doi.org/10.1016/j.placenta.2014.07.004

MLA:

Vierling, F., et al. "Surprising prenatal toxicity of epidermal lipoxygenase-3." Placenta 35.9 (2014): 776-9.

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