Chronicles of a switch hunt: gcm genes in development

Wegner M (2001)

Publication Type: Journal article, Review article

Publication year: 2001


Publisher: Elsevier

Book Volume: 17

Pages Range: 286-90

Journal Issue: 5

DOI: 10.1016/S0168-9525(01)02275-2


Co-conservation of sequence and function is an important principle during evolution. As a consequence, sequence-related genes often have similar functions in evolutionarily distant species. Enter the 'glial cells missing' (gcm) genes. They code for a small family of novel transcription factors that share DNA-binding properties and domain structure. However, no evolutionarily conserved function is apparent as yet. The prototypical gcm from Drosophila dominates nervous system development as a fate switch and master regulator of gliogenesis, whereas mammalian gcm genes have roles in placental morphogenesis and development of the parathyroid gland. Apparently, structure and function sometimes can go separate ways.

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How to cite


Wegner, M. (2001). Chronicles of a switch hunt: gcm genes in development. Trends in Genetics, 17(5), 286-90.


Wegner, Michael. "Chronicles of a switch hunt: gcm genes in development." Trends in Genetics 17.5 (2001): 286-90.

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