Design of simulated moving bed processes under reduced purity requirements

Kaspereit M, Seidel-Morgenstern A, Kienle A (2007)

Publication Language: English

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2007


Publisher: Elsevier

Book Volume: 1162

Pages Range: 2-13

DOI: 10.1016/j.chroma.2007.02.063


The design of simulated moving bed chromatography under reduced purity requirements is investigated. A parametric study indicates that all internal flow rates should be considered as free parameters in process design. This is confirmed by systematic numerical optimisations of two different design scenarios. A restrictive scenario requires complete regeneration of liquid and solid phases. In contrast, in a non-restrictive design all flow rates are optimised. The latter leads to significantly improved process performance. On the basis of the obtained observations, a simple design method for simulated moving bed processes with desired outlet purity values is derived from equilibrium theory. © 2007 Elsevier B.V. All rights reserved.

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How to cite


Kaspereit, M., Seidel-Morgenstern, A., & Kienle, A. (2007). Design of simulated moving bed processes under reduced purity requirements. Journal of Chromatography A, 1162, 2-13.


Kaspereit, Malte, Andreas Seidel-Morgenstern, and Achim Kienle. "Design of simulated moving bed processes under reduced purity requirements." Journal of Chromatography A 1162 (2007): 2-13.

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