Non-invasive computed fractional flow reserve from computed tomography (CT) for diagnosing coronary artery disease - Japanese results from NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps)

Miyoshi T, Osawa K, Ito H, Kanazawa S, Kimura T, Shiomi H, Kuribayashi S, Jinzaki M, Kawamura A, Bezerra H, Achenbach S, Norgaard BL (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Circulation Journal The Japanese Circulation Society

Book Volume: 79

Pages Range: 406-12

Journal Issue: 2

DOI: 10.1253/circj.CJ-14-1051

Abstract

Recently, a non-invasive method using computational fluid dynamics to calculate vessel-specific fractional flow reserve (FFRCT) from routinely acquired coronary computed tomography angiography (CTA) was described. The Analysis of Coronary Blood Flow Using CT Angiography: Next Steps (NXT) trial, which was a prospective, multicenter trial including 254 patients with suspected coronary artery disease, noted high diagnostic performance of FFRCT compared with invasive FFR. The aim of this post-hoc analysis was to assess the diagnostic performance of non-invasive FFRCT vs. standard stenosis quantification on coronary CTA in the Japanese subset of the NXT trial.A total of 57 Japanese participants were included from Okayama University (n=36), Kyoto University (n=17), and Keio University (n=4) Hospitals. Per-patient diagnostic accuracy of FFRCT(74%; 95% confidence interval [CI]: 60-85%) was higher than for coronary CTA (47%; 95% CI: 34-61%, P<0.001) arising from improved specificity (63% vs. 27%, P<0.001). FFRCT correctly reclassified 53% of patients and 63% of vessels with coronary CTA false positives as true negatives. When patients with Agatston score >1,000 were excluded, per-patient accuracy of FFRCT was 83% with a high specificity of 76%, similar to the overall NXT trial findings.FFRCT has high diagnostic performance compared with invasive FFR in the Japanese subset of patients in the NXT trial.

Authors with CRIS profile

Stephan Achenbach Lehrstuhl für Innere Medizin II

Additional Organisation(s)

Department of Medicine 2 – Cardiology and Angiology

Involved external institutions

Okayama University Hospital JP Japan (JP) Kyoto University Hospital / 京都大学医学部附属病院 JP Japan (JP) Keio University Hospital JP Japan (JP) University Hospitals of Cleveland / Case Western Reserve University Hospital US United States (USA) (US) Aarhus University DK Denmark (DK)

How to cite

APA:

Miyoshi, T., Osawa, K., Ito, H., Kanazawa, S., Kimura, T., Shiomi, H.,... Norgaard, B.L. (2015). Non-invasive computed fractional flow reserve from computed tomography (CT) for diagnosing coronary artery disease - Japanese results from NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). Circulation Journal, 79(2), 406-12. https://doi.org/10.1253/circj.CJ-14-1051

MLA:

Miyoshi, Toru, et al. "Non-invasive computed fractional flow reserve from computed tomography (CT) for diagnosing coronary artery disease - Japanese results from NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps)." Circulation Journal 79.2 (2015): 406-12.

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