A highly efficient type I β-turn mimetic simulating an asx-pro-turn-like structure

Pinsker A, Einsiedel J, Härterich S, Waibel R, Gmeiner P (2011)

Publication Language: English

Publication Type: Journal article, Original article

Publication year: 2011

Journal

Organic Letters American Chemical Society

Original Authors: Pinsker A., Einsiedel J., Harterich S., Waibel R., Gmeiner P.

Publisher: American Chemical Society

Book Volume: 13

Pages Range: 3502-3505

Journal Issue: 13

DOI: 10.1021/ol201313q

Abstract

Asx-Pro-turns have been identified with high frequency in protein structures nucleating type I β-turns. By bridging the amino acid side chain in position i with a nitrogen substituent in position i+2 by ring-closing olefin metathesis (RCM), peptide mimetics of type 1 could be developed. NMR based conformational investigations indicated a stable intramolecular H-bond constraining a U-turn conformation that was predicted to simulate a type I β-turn. © 2011 American Chemical Society.

Authors with CRIS profile

Jürgen Einsiedel Lehrstuhl für Pharmazeutische Chemie Reiner Waibel Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie

Additional Organisation(s)

Emil-Fischer-Zentrum (Emil Fischer Center)

How to cite

APA:

Pinsker, A., Einsiedel, J., Härterich, S., Waibel, R., & Gmeiner, P. (2011). A highly efficient type I β-turn mimetic simulating an asx-pro-turn-like structure. Organic Letters, 13(13), 3502-3505. https://doi.org/10.1021/ol201313q

MLA:

Pinsker, Andrea, et al. "A highly efficient type I β-turn mimetic simulating an asx-pro-turn-like structure." Organic Letters 13.13 (2011): 3502-3505.

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