The trick of the tail: protein-protein interactions of metabotropic glutamate receptors.

Enz R (2007)


Publication Type: Journal article

Publication year: 2007

Journal

Book Volume: 29

Pages Range: 60-73

Journal Issue: 29

DOI: 10.1002/bies.20518

Abstract

It was initially believed that G-protein-coupled receptors, such as metabotropic glutamate receptors, could simply be described as individual proteins that are associated with intracellular signal cascades via G-proteins. This view is no longer tenable. Today we know that metabotropic glutamate receptors (mGluRs) can dimerize and bind to a variety of proteins in addition to trimeric G-proteins. These newly identified protein interactions led to the discovery of new regulatory mechanisms that are independent of and sometimes synergistic with the classical G-protein-coupled second messenger pathways. Notably, several of these mechanisms connect mGluR-mediated signaling to other receptor classes, thereby creating a network of different receptor types and associated signal cascades. The intracellular C-termini of mGluRs play a key role in the regulation of these networks, and various new protein interactions of these domains were described recently. Because mGluRs are involved in a variety of physiological and pathophysiological processes, some of the proteins interacting with this receptor class have potential as valuable pharmaceutical targets. This review will give a comprehensive overview of proteins interacting with mGluR C-termini, highlight new evolving regulatory mechanisms for glutamatergic signal transduction and discuss possibilities for future drug development. © 2006 Wiley Periodicals, Inc.

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How to cite

APA:

Enz, R. (2007). The trick of the tail: protein-protein interactions of metabotropic glutamate receptors. Bioessays, 29(29), 60-73. https://dx.doi.org/10.1002/bies.20518

MLA:

Enz, Ralf. "The trick of the tail: protein-protein interactions of metabotropic glutamate receptors." Bioessays 29.29 (2007): 60-73.

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