Process Concepts in Preparative Chromatography

Kaspereit M, Seidel-Morgenstern A (2013)

Publication Language: English

Publication Status: Published

Publication Type: Book chapter / Article in edited volumes

Publication year: 2013

Publisher: Elsevier Inc.

Edited Volumes: Liquid Chromatography - Fundamentals and Instrumentation

City/Town: Waltham/MA

Pages Range: 427-452

ISBN: 9780124158078

DOI: 10.1016/B978-0-12-415807-8.00019-5


This chapter describes rivalling operating modes applied industrially in preparative chromatography. After recapitulating the basic features of the "workhorse" and reference in the field, namely, isocratic batch elution, at first, more-sophisticated concepts are presented that offer additional degrees of freedom but maintain the discontinuous character of the separation process. Subsequently, process options are described that possess the potential to perform the separations continuously. Hereby, mainly the most successful multicolumn concepts are explained, which are based on realizing highly efficient countercurrent transport processes. Finally, the important aspect is addressedL how different process alternatives can be evaluated and compared quantitatively. © 2013 Elsevier Inc. All rights reserved.

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How to cite


Kaspereit, M., & Seidel-Morgenstern, A. (2013). Process Concepts in Preparative Chromatography. In Salvatore Fanali, Paul R. Haddad, Colin Poole, Peter Schoenmakers, David K. Lloyd (Eds.), Liquid Chromatography - Fundamentals and Instrumentation. (pp. 427-452). Waltham/MA: Elsevier Inc..


Kaspereit, Malte, and Andreas Seidel-Morgenstern. "Process Concepts in Preparative Chromatography." Liquid Chromatography - Fundamentals and Instrumentation. Ed. Salvatore Fanali, Paul R. Haddad, Colin Poole, Peter Schoenmakers, David K. Lloyd, Waltham/MA: Elsevier Inc., 2013. 427-452.

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